State Of The Art Symposium 4: Glomerulonephritis

SLE - New Insight into Pathogenesis and Treatment

Lupus nephritis is a severe complication of systemic lupus erythematosus (SLE) and is a significant cause of morbidity and mortality in patients with SLE. The pathogenesis of lupus nephritis is complex and involves a combination of genetic, environmental, and immunological factors. Recent advances in our understanding of the pathophysiology of lupus nephritis have led to the development of new therapeutic strategies. This talk will provide an overview of the pathogenesis of lupus nephritis, with a focus on the role of immune dysregulation, complement activation, and genetic susceptibility. The speaker will discuss recent insights into the pathophysiology of lupus nephritis, including the role of cytokines, chemokines, and cell signalling pathways. In particular, will highlight the importance of the type I interferon pathway in the pathogenesis of lupus nephritis and its potential as a therapeutic target. The current treatment options for lupus nephritis, including corticosteroids, immunosuppressive agents, and biologics will be reviewed. The speaker will discuss the advantages and disadvantages of these therapies and explore the emerging role of precision medicine in the treatment of lupus nephritis. Finally, the speaker will discuss the challenges and opportunities in the development of new therapies for lupus nephritis. Hopefully, this talk will provide valuable insights into the pathogenesis and treatment of lupus nephritis.